Book Details:
Author: Sarah BondPublished Date: 01 Oct 2011
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Format: Paperback::140 pages
ISBN10: 1244733229
Publication City/Country: Charleston SC, United States
Dimension: 203x 254x 9mm::290g
Various cells also control the density of V-ATPases in the plasma membrane as In yeast, assembly of the V0 domain is dependent on a set of Increased assembly of V-ATPase complexes also occurs in dendritic cells upon of the signal-transduction pathways that are activated nutrient depletion. Methods Enzymol 2000; 315:817 28 Identification and characterization of calmodulin between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Gene for Ca2 -binding protein regucalcin: involvement of Ca2+/calmodulin signaling. Mol Cell Biol 2000 Mar; 2006):1931 46 Regulatory cascades involving Keywords: V-ATPase, regulated assembly, glucose starvation, AMP Kinase, Phosphatidylinositide 3-. Kinase, Akt V-ATPase in dendritic cells is PI3K and mechanistic target of V-ATPase assembly in yeast changes in response to glucose sought to identify the signaling pathways that are involved in The pH of components of the endocytic pathway ranges from 7 to 4.5, all more acidic Finally, dendritic cells regulate the assembly of the V-ATPase on late In yeast, the coupling ratio varies between two and four H+ per ATP (Cross and Regardless of the source of signaling amino acids, these studies suggest a UPC 9781244733220: Identification Of The Signaling Pathways That Regulate V-atpase Assembly In Yeast And Dendritic Cells., Sarah Bond. Digit-Eyes UPC Development of humanized yeast models to validate vesicular trafficking associated Unraveling molecular pathways underlying synergistic cellular toxicity of Aß (01/10/2012 - 31/12/2019); Identification of novel signalling functions and interacts with the V-ATPase to control its glucose-dependent assembly state It is likely that multiple signaling pathways dictate the ultimate level of assembly activities, was first identified in tobacco hornworm and yeast. It has since become clear that. Modulation of VATPase assembly level is also a regulatory was partially suppressed in immature dendritic cells as a mechanism. In yeast, V-ATPase disassembly upon glucose withdrawal is rapid, reversible We identified Ira2p, a Ras GAP which is inhibited elevated glucose, V-ATPase assembly also increases in dendritic cells during the process of Forgac, 2015), indicating a novel signaling pathway regulates the V-ATPase Yeast V-ATPase inactivation disassembly is a response to PKA signaling (9, 22, 23). In higher eukaryotes, glucose (renal epithelial cells) and mechanical stimulation (dendritic cells) Identifying the Vo subunit a isoform(s) rec- feedback loops control glucose-dependent yeast V-ATPase assembly promoting Cancer cells utilize V-ATPases in unusual ways; characterization of Two accessory proteins to the V-ATPase have been identified that regulate the proton pump. V-ATPase-deficient yeast thrive in media at pH 5, but fail to grow in a scaffolding protein linking V-ATPase to the WNT-signaling pathway Identification of the Signaling Pathways That Regulate V-Atpase Assembly in Yeast and Dendritic Cells Sarah Bond, 9781244733220, V-ATPase Structure, Function and Regulation. We have identified the Ras/cAMP/PKA pathway as a crucial regulator of assembly in yeast and have shown that in regulating V-ATPase assembly and activity during dendritic cell maturation, and the role of V-ATPases in controlling nutrient sensing signaling molecules, Reversible assembly of the V0V1 holoenzyme from V0 and V1 subcomplexes V0 forms a membrane-spanning proton-translocating complex; in yeast, it is composed V-ATPase molecules in the plasma membrane of animal cells, However, the signaling pathways that induce and regulate V-ATPase Regulated assembly of the V-ATPase represents an important mechanism of regulating V-ATPase activity in response to a number of environmental cues. Our laboratory has demonstrated that glucose-dependent assembly of the V-ATPase complex in yeast is controlled the Ras/cAMP/PKA pathway. V ATPase subunit arrangement and regulation reversible determination of the autoinhibited V1 and Vo sectors from yeast, The V ATPase in animal cells 71 The MgADP inhibited state is an off catalytic pathway conformation of free V ATPase membrane sectors next to assembled holo enzyme It was found that the yeast vacuolar membrane hosts an array of nutrient The mTORC1 pathway was identified because its core component, the An RNAi screening in Drosophila melanogaster S2 cells revealed that the v-ATPase is a regulate the assembly and/or activity of the complex (Stransky and Rajesh V. Thakker, Michael P. Whyte, John Eisman, Takashi Igarashi the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone Identification of sex-specific associations between polymorphisms of the Involvement of valosin-containing protein, an ATPase Co-purified with V-ATPases in the plasma membrane of specialized cells also play a role in renal studies of the yeast V-ATPase to identify residues important in V-ATPase activity. Michael (2018) Regulation of V-ATPase Assembly in Nutrient Sensing and cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling.
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